Flavonoids, a new treatment for amebiasis
DOI:
https://doi.org/10.30973/inventio/2024.20.52/7Keywords:
Amoebiasis, Flavonoids, New Compounds, Entamoeba histolyticaAbstract
Entamoeba histolytica is the parasite that causes amebiasis, this organism invades the large intestine and causes lesions at the level of the colon and can spread systemically to other organs such as the liver where it leads to the formation of amoebic liver abscess, in severe clinical conditions patients can die. WHO reports that it mainly affects people in developing countries, such as Mexico, where it is estimated to affect 40% of the population. The most commonly used treatments for amoebiasis are nitroimidazoles, and although metronidazole is the standard treatment, it can cause adverse effects. It is therefore important to look for new treatments that are not toxic to humans and that are accessible and inexpensive. For this reason, the use of medicinal plants is one of the most sought-after options for many researchers. Flavonoids are phytonutrients found in plants. These compounds are known to have antiparasitic, antioxidant, anti-inflammatory, antispasmodic, anti-ulcer and immunoregulatory effects. Studies have investigated the effect of flavonoids such as camperol and epicatechin on Entamoeba histolytica trophozoites. The results of the use of flavonoids are encouraging and in the future they could be evaluated as an effective antihelminthic drug and become a better treatment against this pathology.
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Copyright (c) 2024 Munich Guevara Rubio, Ivonne Maciel Arciniega Martínez, Aldo Arturo Reséndiz Albor, Nadia Mabel Pérez Vielma, Germán Higuera Martínez, David Levaro Loquio, Maritza Velásquez Torres, Judith Pacheco Yépez
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