Identification of linear peptides as in silico immunogenic leads against Anaplasma marginale
DOI:
https://doi.org/10.30973/inventio/2024.20.50/1Keywords:
bovine anaplasmosis, immunoprotection, diagnosis, immunobioinformatics, vaccinologyAbstract
Anaplasma marginale is a pathogen with a wide genetic diversity, which has hindered the development of efficient vaccines for the prevention and control of bovine anaplasmosis. Using bioinformatics programs, a prediction of linear peptides of membrane proteins containing B epitopes in their sequence was carried out for their possible proposal as immunogen candidates. This work is an in silico approach for the subsequent synthesis in synthetic multiantigenic peptide (MAP) format and its subsequent in vivo evaluation, in order to analyze the effectiveness in the generation of a protective immune response against a heterologous challenge with strains of Anaplasma marginale.
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Copyright (c) 2005 Cristopher Favian Guadarrama Albarrán, Elizabeth Salinas Estrella, Mayra Elizeth Cobaxin Cárdenas, Sergio Darío Rodríguez Camarillo
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Esta revista proporciona acceso abierto inmediato a su contenido, con base en el principio de ofrecer al público un acceso libre a las investigaciones para contribuir a un mayor intercambio global de conocimientos. Se distribuye bajo una licencia Creative Commons Reconocimiento-NoComercial 4.0 Internacional License.
